Research use only. All analyses are in silico hypothesis generation tools.
DNAI Validation Lab (RUO)

Test your hypothesis on our infrastructure.

You bring the question and the data. We run it through DNAI's research-grade pipeline — multi-omics encoding, physics-constrained simulation, uncertainty quantification — and return a structured report with metrics, artifacts, and explicit limitations. No model access required. No integration work.

Black-box execution
Structured deliverables
Your IP stays yours

Two Productized Engagements

Each engagement is scoped, priced, and delivered as a fixed-scope project. No open-ended consulting.

SKU 1

Reality Check

External Cohort Evaluation (RUO)

You have a cohort, a biomarker, or a model output you want to stress-test. We encode your data through DNAI's pipeline and quantify discrimination, calibration, and applicability — showing where the signal holds, where it degrades, and where the model abstains.

Per-cancer concordance index with confidence intervals
Transportability certificates (GREEN / YELLOW / RED)
Distribution shift diagnostics vs. training data
Calibration curves at 1yr / 2yr / 3yr / 5yr horizons
Structured abstention analysis with per-patient confidence
Typical scopeFixed-price engagement
4–6 weeks
RNA-seq minimum
SKU 2

Preclinical Translation Bridge

PDX-to-Patient Translation Diagnostics (RUO)

You have PDX data and want to understand how it maps to human biology. We run your preclinical data through DNAI's Domain Separation Network to disentangle tumor biology from species-specific stroma, then generate human-scale analog trajectories under explicit assumptions — with quantified translation confidence.

PDX-to-human latent space alignment via DSN
Per-model translation confidence scores (HIGH / MEDIUM / LOW)
Human-scale analog trajectories under stated scaling assumptions
Per-pathway fidelity analysis (intrinsic vs. TME)
Biological validity gates (e.g., IO blocked for PDX — no immune system)
Typical scopeFixed-price engagement
6–8 weeks
PDX RNA-seq + volumes

How an Engagement Works

Fixed scope. No integration required. You never touch our models.

1

Scope

We define the question, data requirements, and success criteria together. Fixed deliverables, fixed timeline.

2

Transfer

You send de-identified data via secure channel. We run automated QC checks and confirm data integrity.

3

Execute

We run the full DNAI pipeline on your data. Gene alignment, VAE encoding, Hypernet simulation, safety checks.

4

Deliver

Structured report with metrics, visualizations, and honest limitations. Optional review call to discuss findings.

Why Use the Validation Lab

You get the output of a production-grade pipeline without the cost of building one.

Speed Without Integration

No API integration, no model deployment, no infrastructure. Send data, get results. Weeks, not quarters.

Your IP Stays Yours

Black-box execution. You receive reports and machine-readable artifacts — not model weights or code. Your data is processed in isolated environments, never used to retrain our base models, and retention terms are defined by contract.

Honest About Limits

Every report includes what we can and cannot say. Structured abstention, distribution shift diagnostics, and per-cancer reliability tiers.

The Pipeline Behind the Report

The same production infrastructure that powers dnai.bio

Multi-Omics VAE
328d structured latent space. RNA, DNA, CNV, methylation. 33 cancer types.
Physics-Constrained ODE
Lotka-Volterra dynamics with hard biological bounds. 0% violation rate in validation.
Structured Abstention
OOD detection, ISS scores, and per-cancer reliability tiers. The model says "I don't know."
Sim-to-Real DSN
Domain Separation Network disentangles species-specific stroma from conserved tumor biology. Patented.

Who Uses the Validation Lab

Biopharma R&D

Preclinical & translational teams

"We have PDX response data on our compound. Can we explore which human patient subtypes show differential simulated sensitivity?"

"We ran a Phase II. Can we retroactively identify the molecular subgroup that benefited most?"

"We want an independent external validation of our biomarker on DNAI's 9,400-patient reference cohort."

Academic Research

Translational oncology groups

"We have a sarcoma cohort with RNA-seq and outcomes. Can DNAI stratify them by simulated treatment sensitivity?"

"We discovered a biomarker in glioma. Can we test it against DNAI's latent space and external validation cohorts?"

"We want per-patient digital twins with pathway attribution for a grant submission."

What's Included

Standard deliverables for each engagement type

DeliverableReality CheckTranslation Bridge
Gene alignment + data QC report
Per-cancer C-index with confidence intervals
Transportability certificates (GREEN/YELLOW/RED)
Distribution shift diagnostics
Per-horizon calibration curves
Structured abstention analysis
DSN alignment + translation confidence
Per-pathway fidelity scores
Human-scale analog trajectories
Biological validity gates
Summary report with limitations
Review call with DNAI team

From Evaluation to Partnership

The Validation Lab is a standalone engagement with no follow-on obligation. If the evaluation demonstrates fit for your use case, deeper collaboration is an option — not an expectation.

Start Here
Validation Lab
Fixed scope, no commitment
If Fit Demonstrated
Platform Access
Self-serve simulation tools
Long-Term
Research Partnership
Co-development, publications

Data Requirements

Reality Check (SKU 1)

RNA-seq expression (TPM or FPKM, minimum)
Survival endpoint (OS or PFS with censoring)
Optional: DNA mutations, CNV, methylation, WSI
Optional: Treatment history for CATE analysis
Minimum cohort: 50 patients with events

Translation Bridge (SKU 2)

PDX RNA-seq expression (TPM or FPKM)
Tumor volume measurements (time series)
Optional: Drug annotations per model
Optional: Untreated control arm volumes
All data must be de-identified before transfer

What the Validation Lab Is Not

Not a regulatory submission service — all outputs are for research use only
Not open-ended consulting — engagements are scoped and time-boxed
Not a model handoff — you receive reports and artifacts, not weights or code
Not a clinical validation — all simulations are in silico hypothesis generation

Research use only

All Validation Lab outputs are intended for research purposes and in silico hypothesis generation. They are not validated for regulatory submissions, clinical decision-making, or patient selection.

Let's define your first engagement

Tell us about your data and your question. We'll scope a fixed deliverable and timeline within a week.